The ongoing crisis in multilateralism represents a significant transformation in the international order. Escalating tensions between China and the United States, the resurgence of nationalism, increased disputes over international institutions, and the proliferation of global crises have collectively rendered the multilateral system increasingly fragile (Acharya, 2014; Ikenberry, 2011). Africa relies on these systems for security and development, and as external powers intensify their engagement with the continent, Africa assumes a pivotal role in these global dynamics (Adebajo, 2016; Zartman, 2018). This article analyzes the challenges confronting Africa and the opportunities emerging from the erosion of multilateralism. It argues that Africa can enhance its autonomy and global influence through regional cooperation and the diversification of partnerships. Consequently, a revitalized African multilateralism is positioned as an essential instrument for advancing the continent’s interests within a multipolar world.