Telemedicine has become an essential component of healthcare delivery, particularly during and after the COVID-19 pandemic. Despite its rapid expansion, utilization of telemedicine services remains uneven, influenced by various individual and contextual factors. Objective: This study aimed to review factors influencing the use and adoption of telemedicine services, with a focus on education level, knowledge, and attitudes. A literature review was conducted using Google Scholar to identify relevant quantitative studies published between 2021 and 2025. Articles were selected based on predefined inclusion and exclusion criteria, including open-access availability, full-text access, and relevance to telemedicine utilization. Six articles met the criteria and were included in the review. The findings indicate that education level shows inconsistent associations with telemedicine utilization and tends to influence adoption indirectly through digital literacy and access to technology. Knowledge consistently emerged as a significant determinant of telemedicine use, with higher knowledge levels increasing the likelihood of utilization. Attitudes toward telemedicine, particularly perceived usefulness, ease of use, and trust, were found to significantly influence intention to adopt and actual use of telemedicine services. Telemedicine utilization is primarily driven by cognitive and perceptual factors rather than education level alone. Enhancing knowledge and fostering positive attitudes toward telemedicine are essential to improving adoption and sustainable use. Targeted educational interventions and efforts to improve digital literacy are recommended to optimize telemedicine implementation.